What to do if…
you develop new yellowing of the eyes or skin that comes on quickly
Short answer
New, fast-onset yellowing of the eyes or skin is an urgent medical symptom: get evaluated today (the ER is appropriate if you can’t get immediate care). If you feel very sick, confused, faint, or have severe pain, call 911.
Do not do these things
- Do not wait “a couple days” to see if it goes away when the yellowing is new and came on quickly.
- Do not drink alcohol or take recreational drugs to “take the edge off.”
- Do not take extra acetaminophen (Tylenol) or stack multiple cold/flu products that may contain acetaminophen.
- Do not stop prescription medicines on your own unless a clinician instructs you to. If you think you may have taken too much acetaminophen or another medication, get urgent help immediately.
- Do not drive yourself if you feel dizzy, drowsy, confused, faint, or in significant pain—get a ride or call 911 if needed.
What to do now
- Go to the ER now or call 911 if you have any emergency signs:
- confusion, extreme sleepiness, fainting/collapse, a seizure, or you can’t be awakened
- trouble breathing, chest pain, or severe weakness
- severe abdominal pain (especially upper right) or pain that’s rapidly worsening
- repeated vomiting, vomiting blood, or black/tarry stools
- high fever with shaking chills, or you look/feel rapidly worse
- If no emergency signs, still get same-day evaluation:
- Call your primary care office and say: “New jaundice—yellow eyes/skin that came on quickly. I need same-day evaluation.”
- If you can’t be seen quickly, go to the ER. (Urgent care can be reasonable only if they can evaluate you promptly and send labs/imaging or refer you immediately—if not, choose the ER.)
- If there’s any chance of too much acetaminophen (Tylenol) or a medication/supplement reaction:
- Call Poison Control at 1-800-222-1222 right away (or use their online tool). If the person collapses, has a seizure, has trouble breathing, or can’t be awakened: call 911.
- Bring the bottles/labels (or clear photos of them) with you.
- If you are pregnant:
- Call your OB/midwife now for same-day instructions. If you can’t reach them quickly and symptoms are new/fast, go to Labor & Delivery (if that’s your local norm) or the ER.
- Get ready for the visit while you’re arranging care:
- Write down: when yellowing started, how fast it changed, dark urine, pale stools, itch, fever, nausea/vomiting, abdominal pain.
- Gather: all prescription/OTC meds, vitamins, herbals, and supplements (photos of labels are fine).
- Arrange someone to stay with you or check in, and get a safe ride.
What can wait
- You do not need to identify the exact cause before being seen.
- You do not need to start “cleanses,” fasting, or restrictive diets.
- You do not need to make big decisions about work/travel today—your only job is to get evaluated safely.
Important reassurance
Yellowing that appears quickly can feel alarming, and it’s reasonable to be worried. Getting checked promptly is the right move and helps clinicians catch treatable problems early and prevent avoidable harm.
Scope note
This guide covers immediate, first-step actions for new, fast-onset jaundice. Diagnosis and treatment require an in-person evaluation (often blood tests and sometimes imaging).
Important note
This is general information, not medical advice or a diagnosis. If you feel severely unwell, are getting worse quickly, or are not safe to travel by car, call 911.